pPLUS® AAV-RC range is a set of ready-to-use RepCap plasmids for AAV production of various serotypes through triple transfection. Optimized for use w...

Cell and Gene Therapy
Transfection reagent for lentiviral vector production from small to large scale
Productivity
Reach highest Lentiviral vectors titers in suspension systems
Cost-effectiveness
Reduce your cost per batch with high titers and low DNA consumption
Scalability
Produce at large scale with low complexation volume and long complex stability
Time saving
Use DOE service to help you optimize your process in a record time
Product information | Ready to use, synthetic and free of any animal-origin component |
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Applications | Lentiviral vectors (LV) manufacturing using HEK-293 derivative cells cultivated in suspension |
Number of transfections | 100 mL of FectoVIR®-LV transfection reagent is sufficient to transfect on average 50 L of cell culture (using standard conditions) |
Storage condition | Store FectoVIR®-LV at 5 °C ± 3°C. |
Product documentation | Protocol |
Lentiviral vectors are recognized to be the carrier of choice for allogenic or autologous cell therapies (such as CAR-T) because of its capacity to permanently integrate viral genome into host cell DNA. To produce those vectors, cell therapy producers generally use a transient transfection system that is scaled-up during process development phases. FectoVIR®-LV is the next generation of transfection reagent, free of animal component, designed to improve LV productivity in HEK-293 cell systems. FectoVIR®-LV is made for large scale manufacturing with reduction of the complexation volume and increased complex stability. The FectoVIR®-LV benefits allow to increase number of doses produced per batch to treat more patient, while decreasing LV manufacturing costs.
Discover Polyplus’ complementary DOE service to fast-track optimization of lentivirus production with FectoVIR®-LV.
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