PEIpro® is the leading PEI-based DNA transfection reagent that offers flexibility and scalability for viral vector manufacturing.
Summary
Check out this new webinar hosted by BioInsight and featured by experts in transfection working at Polyplus-transfection®, Audentes Therapeutic, Pall Life Sciences & Paragon Bioservices. This webinar on "Optimizing process development to simplify manufacturing scale up of therapeutic viral vectors" is followed by a Question & Answer Session.
Several topics are covered around the optimization of manufacturing scale-up of therapeutic viral vectors to support advanced clinical trials and commercialization.
Webinar on process development to manufacturing scale-up of therapeutic viral vectors
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0:19 Introduction to the webinar
2:10 Presentation of Polyplus-transfection
2:57 Transfection product lines
3:56 Viral Vectors Manufacturing Roadmap
6:59 Current Upstream Manufacturing Challenges
8:15 Optimized PEI for Viral Vector Production: PEIpro® product range
12:02 Scaling-up systems: adherent and suspension
14:00 Scalable transient transfection: cell culture medium
18:35 Production scale-up
21:20 PEIpro® product range: from PD with PEIpro® to commercialization with PEIpro®-GMP
Q&A Session
24:40 Experiences of viral vector manufacturing and specific pain points in scaling-up
29:45 Adherent VS suspension
36:30 Transfection efficiency factors, which criteria need to be monitored in a dynamic process?
42:50 Importance of supplier relationships as you move to commercial scale?
49:30 Could regulatory agencies ask for a QC on residual presence of PEIpro® within the final product?
50:17 Is Metabolomic used to understand the bioprocess system and how efficient transfection is?
52:55 What further improvements to look for in viral vector manufacturing process?
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