in vivo-jetPEI® is a ready-to-use cationic polymer reagent recommended for in vivo transfection of DNA, siRNA, miRNA, shRNA and other oligonucleotide...
Specifications
Type | Ready-to-use lipid-based nanoparticles |
---|---|
Molecule delivered | mRNA, saRNA, gRNA |
Biodistribution & Injection routes | Universal biodistribution: Any organ or tissue (depending on the injection route) |
Number of injections in mice | 1 mL is sufficient to perform 50 intravenous injections or 100 intramuscular injections in mice |
Storage | Store in vivo-jetRNA®+ at 5 ± 3°C. Do not freeze. |
Provided with | mRNA buffer |
Overview
in vivo transfection reagents are the most powerful alternative to viral vectors for nucleic acid delivery. They are easy to use, cost-effective and considered as safe and efficient vehicles for RNA delivery. mRNA transfection is rapidly emerging as a promising method for nucleic acid-based therapy and offers an attractive substitute to plasmid DNA. Non-viral mRNA delivery methods have already proven their efficiency in vaccination through antigen presenting cells modification and in anti-cancer therapy by directly targeting malignant cells. The intrinsic advantage of mRNA-based immunotherapy relies on the self-adjuvant activity of mRNA and the fact that small amounts of encoded antigen are sufficient to obtain robust immune response.
in vivo-jetRNA®+ is a non-viral delivery solution composed of pre-formed lipid-based nanoparticles. It was specifically developed for in vivo mRNA delivery. Its high delivery efficiency combined with its safety make in vivo-jetRNA®+ an innovative alternative to lipid nanoparticles (LNPs), with the added advantage of being user-friendly with a 2-step protocol.
in vivo-jetRNA®+ can be used to deliver mRNA, saRNA and gRNA via systemic or local administration routes in various animal models, making it an ideal tool for scientists developing vaccines, protein replacement therapies, performing oncology studies, or working on genome editing. It has also proved highly effective for ex vivo applications, such as the generation of mRNA CAR-T cells.
Next generation lipid-based delivery for mRNA therapeutics: in vivo-jetRNA®+
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