Citation

  • Authors: Zhu, S., Jiang, X., Jiang, S., Lin, G., Gong, J., Chen, W., He, Z., Chen, Y. Q.
  • Year: 2018
  • Journal: Cell Biol Int 42 180-186
  • Applications: in vitro / siRNA / jetPRIME
  • Cell types:
    1. Name: HCC1806
      Description: Human breast carcinoma cell line
    2. Name: MCF 10A
      Description: Human breast adenocarcinoma cells
      Known as: MCF10A, MCF 10A
    3. Name: MCF7
      Description: Human breast adenocarcinoma cells
      Known as: MCF-7, MCF 7
    4. Name: MDA-MB-231
      Description: Human breast adenocarcinoma cells
      Known as: MDAMB231
    5. Name: MDA-MB-361
      Description: Human breast adenocarcinoma cells
    6. Name: SK-BR-3
      Description: Human mammary gland adenocarcinoma
    7. Name: T-47D
      Description: Human breast ductal carcinoma cells
      Known as: T 47

Abstract

Intake of omega-3 PUFAs reduces the frequency of breast cancer, and GPR120 receptor transduces omega-3 PUFAs signaling to increase insulin sensitivity in mice, but whether GPR120 mediates omega-3 PUFAs signaling to inhibit breast carcinogenesis is currently unknown. In the present study, we found that GPR120 is highly expressed in human breast cancerous tissues but not adjacent normal tissue. Knockdown of GPR120 by siRNA in breast cancer cells significantly reduced cell growth, and dramatically increased omega-3 FFA-induced cell growth inhibition and apoptosis. Thus, these observations indicated that GPR120 promotes breast cancer cell growth, whereas omega-3 PUFA-induce breast cancer cell apoptosis independently of GPR120.

Go to