Citation

  • Authors: Zhu L. et al.
  • Year: 2020
  • Journal: Mol Immunol 122 124-131
  • Applications: in vitro / DNA / jetPRIME
  • Cell types:
    1. Name: HEK-293T
      Description: Human embryonic kidney Fibroblast
      Known as: HEK293T, 293T
    2. Name: RAW 264.7
      Description: Mouse monocytes/macrophages
      Known as: RAW

Method

HEK-293: 90% transfection efficiency. RAW264.7: 50% transfection efficiency

Abstract

Thousand and one amino acid kinase 1 (TAOK1) is a member of Ste20-like kinases, but its function in regulating inflammatory responses remains largely unknown. In this study, we identify TAOK1 as a positive regulator of TLR4-triggered inflammatory responses in macrophages. TAOK1 increases LPS-induced production of pro-inflammatory cytokine such as IL-6, TNF-

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