Polyplus Introduces LipidBrick® for LNP Formulation in mRNA Therapeutics

Strasbourg, France, 14 March 2023 – Polyplus, a leading solutions provider for manufacturing of Advanced Therapeutic Medicinal Products from research to commercial grade, is introducing a novel cationic lipid for lipid nanoparticle (LNP) formulation in mRNA therapeutic and vaccine development. Referred to as LipidBrick® IM21.7c, this cationic lipid broadens the scope of LNP usage in various applications from prophylactic vaccines to therapeutic and oncology applications.

LipidBrick IM21.7c overcomes current generation ionizable lipid challenges used in LNP’s, by enabling a wider in vivo biodistribution and decreasing accumulation in the liver. Proof of concept work has demonstrated that due to LipidBrick IM21.7c’s intrinsic properties in modulating the overall charge of LNP’s, it improves drug efficiency and formulation stability without safety issue.

“Polyplus draws on over 20 years legacy in cationic polymer and lipid-based delivery systems for both in vitro and in vivo models to power mRNA therapeutics, said Mario Philips, CEO. “As we carry forward this legacy, we are working to ensure that our offer opens new possibilities to improve LNP formulation to meet the growing demand of the mRNA therapeutic market. LipidBrick IM21.7c is already used in jetMESSENGER® and liposomal formulations for mRNA delivery, as a ready-to-use solution that requires no onsite formulation.”

“In addition, RNA vaccine producers are looking for lipids without intellectual property (IP) constraints. Polyplus has an independent IP on LipidBrick IM21.7c and its imidazolium family of cationic lipid which allows simpler and more cost-effective contracts for direct developers and manufacturers to leverage their offer,” Julien Depollier, Strategic Partnership Director commented.

The new LipidBrick IM21.7c will be made available in April 2023. Please register to our upcoming webinar LipidBrick® IM21.7c: Impact of a novel cationic lipid on both mRNA LNP properties and in vivo biodistribution , or click here to learn more.

About Polyplus

Polyplus is a leading upstream solutions provider for advanced biologic and cell and gene therapy production from research to commercial scale. An innovator in nucleic acid delivery, the legacy portfolio features process-centric transfection reagents, kits, and support services including bioproduction industry standard, PEIpro®. Custom plasmid vector design was integrated into the offer in 2022 as a first measure to expanding the products and services portfolio to help the industry optimize process economics while meeting strict scientific and regulatory standards. Headquartered in Europe, the Polyplus team continues to grow globally with operations in the United States and Asia. Explore us now

Media Contact Information: 

Alengo Nyamay’antu, PhD
Marketing & Communication team leader at Polyplus
Direct: +33 3 88 67 59 38