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jetPEI®
High-Throughput Screening (HTS) is widely used in pharmaceutical industry and basic & translational research to study biological processes. HTS bioassays are almost exclusively conducted in the microtiter plate formats (96, 384 or 1536 wells), which makes the use of a highly reproducible transfection reagent indispensable. jetPEI® transfection reagent is a linear polyethylenimine derivative, free of components of animal origin, ideal for automated...
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jetPRIME®
jetPRIME® is a polyvalent transfection reagent that ensures effective and reproducible DNA and siRNA transfection in several adherent cell lines. This versatile reagent is also perfect for co-transfection of DNA and siRNA. Transfection with jetPRIME® requires only low amounts of nucleic acid, hence resulting in very low cytotoxicity. jetPRIME® is suited for different applications, such as plasmid transfection, gene silencing,...
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LipidBrick® Library
DNA and RNA therapeutics offer promising new treatments for a wide range of diseases, and lipid nanoparticles (LNPs) are an essential tool in their delivery. Those treatments include both prophylactic vaccines that prevent infection by triggering the patient’s immune system and therapeutic vaccines/drugs that will be used to cure a patient from a specific disease. As the properties of LNPs...
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PEIpro®
PEIpro® transfection reagent is the leading PEI-based DNA transfection reagent that offers flexibility and scalability to develop a robust and sustainable viral vector manufacturing process. PEIpro® benefits from extensive research development in PEI polymer chemistry and formulation to achieve highest transfection efficiency in both adherent and suspension cell culture systems. PEIpro® allows a smooth transition from initial process development to...
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Plasmid Engineering Service
At Polyplus, we have developed a unique and innovative DNA assembly technology(e-Zyvec®) to offer tailor-made plasmid engineering and production services for plasmids, from Discovery grade to GMP grade manufacturing. Our e-Zyvec® assembly technology is based on the use of linear DNA bricks, designed and build to produce the final plasmid construct. Plasmid design is therefore flexible and accurate, allowing the...
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Plasmid Manufacturing Service
Fig :Polyplus proposes different quality grades based on the applications (drug substance vs critical starting materiall)  Polyplus offers a comprehensive range of plasmid services including DNA sequence design, optimization and plasmid engineering, cloning, transformation in our proprietary and IP free microbial E. coli, fermentation, patented soft DNA extraction process, single chromatography step and analytical testing. Polyplus has developed an unique...
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pPLUS® AAV-Helper
pPLUS® AAV-Helper is a novel helper plasmid designed for AAV production. This plasmid is the outcome of an extensive R&D program based on our proprietary DNA assembly technology (e-Zyvec® technology) aiming at exploring the synergies of multiple genetic features to improve the infectivity (measured in TU/mL) and quality (full/empty ratio) of viral particles obtained through triple transfection of suspension HEK-293...
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pPLUS® AAV-RC Range
pPLUS® AAV-RC range is a set of RepCap plasmids designed for AAV production of various serotypes. The plasmids have been optimized for use with pPLUS® AAV-Helper in a triple transfection process, providing enhanced AAV yields of high quality and infectivity. The pPLUS® AAV-RC plasmids are readily available at Research Grade and available upon request at GMP grade.    
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Protein Manufacturing Service
We offer an end-to-end integrated protein manufacturing service thanks to our CDMO Xpress Biologics that have since 2014 continuously grown their capabilities to meet current demands to produce recombinant proteins and antibody fragments for preclinical and clinical use, specific to human and veterinary therapeutics, vaccines and diagnostics markets. Both, the production scale from 100 mg up to 40 g and...
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PULSin®
The delivery of protein and antibody using PULSin® represents a powerful approach for functional studies. With PULSin® you can target intracellular proteins with antibodies in living cells without a fixation step, as well as study the function of a protein by controlling the expression level and the expression time course. PULSin® is composed of a proprietary cationic amphiphile molecule that forms...
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