Our fully integrated protein manufacturing services covers all needs from initial process development to manufacturing at research, HQ and GMP grade.
Based on its core know-how in the field of nucleic acid engineering and delivery technology, our R&D teams are focused on developing innovative products for the upstream manufacturing of biologics for advanced medicinal therapy and for the development of nucleic acid-based therapeutics. Our R&D is optimizing key critical components of the manufacturing workflow (plasmids, media, transfection reagents) to increase viral vector titers and quality, and to develop critical materials (plasmids, lipids, polymers) and nanoparticle solutions for novel non-viral RNA/DNA therapeutics.
Our R&D Chemistry Team
Innovates based on the fundamental principles of supramolecular chemistry to develop the most suitable molecule to help our customers overcome current delivery limitations. Our philosophy is to provide innovative solutions to answer the next challenge in nucleic acid. From in vivo-jetPEI® (2001) to LipidBrick® (2023), Polyplus launched more than 20 different reagents, both polymer- or lipid-based for various in vitro and in vivo nucleic acid delivery applications, from large-scale viral vector manufacturing to protein manufacturing.
Our R&D Bioproduction Team
Leverages its combined expertise in transfection, recombinant virus production, and process development to develop innovative solutions for gene therapy manufacturing. By closely collaborating with other R&D teams at Polyplus, the R&D Bioproduction team develops cutting-edge and high performing transfection reagents that address the technical challenges faced by our customers.
Our R&D Life Sciences Team
Dedicated to the screening of innovative molecules (polymer- or lipid-based reagents) for the transfection of cell lines and primary cells with different types of nucleic acids. In collaboration with other R&D teams at Polyplus, the R&D Life Science team develops products used for non-viral in vitro and in vivo nucleic acid delivery and for the transfection or the transduction of immune cells.
Our R&D Genetic Engineering Team
Dedicated to developing new plasmids with novel functionalities (e.g. synthetic promoters, new regulatory sequence) and to improve plasmid scaffolds that are to be proposed to our community of users through our online Web platform. This is achieved in close partnership with the other R&D teams of Polyplus, to create new standard vectors with refined or new functionalities that will improve bioprocesses’ yield and quality. Such plasmid products are then made available at different manufacturing scale and quality grade up to GMP.
Explore All Our Products and Services
Explore our easy plasmid services starting at just $249. Our fully sequenced plasmids, ready for your research, include a miniprep. Reduce project cos...
pPLUS® AAV-Helper is a novel plasmid helper designed for AAV production. This plasmid has been optimized for triple transfection of HEK293 cells in s...
Polyplus® free of charge viral vector DOE service is the combination of our expertise in the field of nucleic acid delivery and in DoE methodology.
Polyplus offers a comprehensive range of plasmid manufacturing services from DNA plasmid design to plasmid DNA manufacturing and analytical testing.
Obtain accurate and reliable full length plasmid sequencing with our Next Generation Sequencing service.
Polyplus provides an integrated service for design and production of tailor-made DNA plasmid through our unique and Innovative assembly technology.
FectoVIR®-LV transfection reagent designed to improve Lentiviral vector (LV) titers in HEK-293 suspension cell systems.
LipidBrick® is a novel range of proprietary cationic lipids dedicated to the formulation of LNPs for the development of mRNA-based vaccines and thera...
in vivo-jetRNA®+ is a lipid-based transfection reagent composed of preformed liposomes specifically developed for in vivo mRNA delivery.
Available at research and GMP grade to intensify production of recombinant AAV rAAV viral vectors at any scale from benchtop to 2000L scale bioreactor...
in vivo-jetPEI® is a ready-to-use cationic polymer reagent recommended for in vivo transfection of DNA, siRNA, miRNA, shRNA and other oligonucleotide...
jetOPTIMUS® is an innovative cationic nanotechnology developed to improve DNA transfection efficiency in hard-to-transfect cells.
FectoCHO® expression system is optimized for culture and transient protein expression of all CHO cells.
PEIpro® is the leading PEI-based DNA transfection reagent that offers flexibility and scalability for viral vector manufacturing.
jetMESSENGER® is a designed for high mRNA transfection efficiency in primary cells, cancer cell lines, neurons, and stem cells.
High-throughput cDNA libraries screening is a valuable tool to study gene expression and regulation and protein interactions and functions.
FectoPRO is a transfection reagent specifically optimized for transient protein and antibody expression in CHO and HEK293 cells.
The delivery of protein and antibody using PULSin® represents a powerful approach for functional studies in live cells.
INTERFERin® provides very high silencing efficiency already at 1 nM siRNA and can be used in a wide variety of adherent and suspension cells....
Discover Our Applications
Cell & Gene Therapy
Success of Gene and Cell Therapies is dependent on efficient production of viral vectors that require optimized transfection reagents and viral vector engineering
RNA/DNA in vivo delivery is the most powerful alternative to viral vectors for nucleic acid-based therapies. They offer substantial advantages in terms of reliability,safety and costs for nucleic-acid based therapies
Broad range of solutions is needed for manufacturing of functional proteins or antibodies at the desired scale in bacteria, yeast and mammalian cell expression systems
Optimised plasmid engineering and specific transfection reagents are key to enable protein expression in a wide range of adherent and suspension mammalian cell types